TNFAIP1 and Alzheimer disease: The transcript levels of TNFAIP1 was found to be robustly induced in the transgenic C. elegans AD brains and post-mortem AD brain in previous study [12, 13], which led us to examine the hypothesis that TNFAIP1 was involved in the pathological development of AD using an in vitro mouse AD model: mouse primary cortical neurons and N2a neuroblastoma cells treated by Aβ25–35.