Despite a recent report that disruptions to molecules in the PSD, such as PSD95 and NR2B subunit-containing N-methyl-D-aspartate receptors are specific to CA3 and not CA1 in schizophrenia,19 our previously reported alterations of mGluR5 and Tamalin in CA123 suggest that disruptions to other important PSD95-complex molecules may exist in the CA1 region in schizophrenia. Here, GRM5 is linked to schizophrenia.