For example, decreased levels of the critical scaffold protein Homer1 were reported in an unspecified region of the hippocampus,22 and increased levels of its related multi-scaffolding protein, Tamalin, was detected in CA1 in schizophrenia subjects.23 Preso proteins have a similar role as Tamalin;24,25 these proteins have been shown to be decreased in the dorsolateral prefrontal cortex in schizophrenia,26 but their status in the hippocampus in schizophrenia remains unknown. The gene discussed is FRMPD4; the disease is schizophrenia.