Preso proteins facilitate PSD95/Homer1 long-isoform interactions with group I mGluRs, and reportedly have a role in dendritic spine morphogenesis.24,25 Considering the aforementioned alterations of PSD95 and Homer1, we additionally assessed protein levels of Preso in the CA1 region in schizophrenia. The gene discussed is FRMPD4; the disease is schizophrenia.