These aberrations in Homer1a and Homer1b/c protein levels resulted in a significant twofold decrease in the ratio of Homer1b/c to Homer1a from 29.11±18.19 to 15.12±13.50 (t35=−2.679, P=0.011), suggesting an imbalance of these proteins in schizophrenia. Here, HOMER1 is linked to schizophrenia.