For example, decreased levels of the critical scaffold protein Homer1 were reported in an unspecified region of the hippocampus,22 and increased levels of its related multi-scaffolding protein, Tamalin, was detected in CA1 in schizophrenia subjects.23 Preso proteins have a similar role as Tamalin;24,25 these proteins have been shown to be decreased in the dorsolateral prefrontal cortex in schizophrenia,26 but their status in the hippocampus in schizophrenia remains unknown. This evidence concerns the gene HOMER1 and schizophrenia.