CX3CR1 and Cognitive impairment: Besides, hAPP-CX3CR1−/− mice as well as hTau-CX3CR1−/− mice showed increased expression of inflammatory factors, enhanced tau phosphorylation, and exacerbated plaque-independent neuronal dysfunction and cognitive deficits [27, 28], while researches also demonstrated that both APP-PS1/CX3CR1−/− and CRND8/CX3CR1−/− mice showed reduction in Aβ deposition with increased number of microglia [29, 30].