IGHE and allergic rhinitis: They named this clinical entity “local allergic rhinitis” (LAR) and demonstrated that in patients with seasonal rhinitis (17), that was labeled as idiopathic because of negative tests, a Th2-IgE-mediated nasal inflammation was present, as demonstrated by a nasal leukocyte-lymphocyte phenotype (CD45, CD33, CD16, CD3, CD4 and CD8), eosinophil-cationic-protein, and total and specific-IgE to grass and olive pollen in nasal lavage (18).