In 2006, Krause et al. [49] demonstrated homing and engraftment of CML LSCs is characterized by dependence on the CD44 receptor and reduced reliance on CXCR4 and its ligand, CXCL12 (Fig. 4). The gene discussed is CXCR4; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.