Everolimus is a derivative of sirolimus, which is approved by the FDA for the treatment of patients with subependymal giant-cell astrocytomas (SEGAs) associated with TSC, and acts similarly to sirolimus as an inhibitor of mTOR; hence, an everolimus trial is currently proceeding to attempt to treat symptomatic patients with inoperable CRs [5, 6]. The gene discussed is MTOR; the disease is tuberous sclerosis.