The build-up of high amounts of oligomeric Aβ induces neuroinflammation, causes oxidative damage and negatively influences multiple signal transduction events including the activation of glycogen synthase kinase-3β (GSK-3β) [125], a pivotal kinase in AD but also for memory consolidation, which limits its use as a target for AD therapy. The gene discussed is GSK3B; the disease is Alzheimer disease.