The expression of MFG-E8 in humans and in some animal models is reduced in autoimmune disease [18], rheumatoid arthritis (RA) [36], sepsis [34, 37–40], acute colitis [20], atherosclerosis [41], ischemia/reperfusion (I/R) injury [42], and Alzheimer's disease [43]. This evidence concerns the gene MFGE8 and autoimmune disease.