MFGE8 and Sepsis: The regulation of MFG-E8 expression in sepsis was also confirmed by another study, which found that MFG-E8 protein levels in CLP rats were decreased in the spleen and the blood, where the clearance of apoptotic cells was impaired, and that the administration of immature dendritic cell- (IDC-) derived exosomes containing MFG-E8 facilitated the phagocytosis of apoptotic cells leading to a reduction in mortality [40].