MAP2K7 and melanoma: As early MAPK pathway inhibitors were known to be multikinase inhibitors that also affected (neo)angiogenesis (e.g., sorafenib inhibits not only RAF but also VEGFR (Vascular Endothelial Growth Factor Receptor) and PDGFR (Platelet Derived Growth Factor Receptor)), we utilized this model to show that the MEK inhibitor AZD6244 despite strong activity in melanoma cells has no significant effect on angiogenesis (Figure 4) [24].