FGFR3 and plasma cell myeloma: In a recent report, Chell et al.28 established a KMS-11 myeloma cell line carrying the FGFR3Y373C mutation with acquired resistance to AZ8010, an FGFR inhibitor, and their sequencing analysis of resistant cells revealed a point mutation at the gatekeeper residue in FGFR3 (FGFR3V555M).