Since SOX9 inhibits CRC cell growth and colonosphere formation and since SOX9 was previously identified as an inhibitor of the activity of the Wnt/ß-catenin signaling pathway, we suspected that the SOX9 induced inhibition of both cell growth and colonosphere formation might result from an inhibition of the activity of the Wnt/ß-catenin signaling. The gene discussed is SOX9; the disease is colorectal carcinoma.