SOX9 and colorectal cancer: The heterogeneity of SOX9 mutations in primary colorectal cancers (http://cancer.sanger.ac.uk/cosmic/) is illustrated in Figure 1A and clearly indicates firstly, that none of the SOX9 domains are spared by mutations and secondly, that the most impacted domains are the DNA binding domain (HMG) and the trans-activating domains (TA).