ANXA2 and glioblastoma: To account for further effects mediated by ANXA2, we generated an enrichment map based on gene ontology (GO) analysis of differentially expressed genes, which clearly showed that ANXA2 blockade is sufficient to significantly down-regulate genes clustering in cell cycle, DNA replication, chromosome segregation and microtubule organization gene families, thus pointing ANXA2 also as a potential modulator of GBM cell proliferation (Figure 2C).