Importantly, GBM patients with an ANXA2 Very Low score (< 25° percentile) display a significant increase in PFS and OS compared to all other GBMs (Figure 1E, 1F, Table 1 and Supplementary Figure S2E, S2F), thus strengthening the correlation of ANXA2 with GBM aggressiveness. The gene discussed is ANXA2; the disease is glioblastoma.