CDH1 and cancer: Although there is controversy as to whether hypermethylation is the most common mechanism of CDH1 silencing associated with the EMT, and conferring more aggressive tumor behavior, it is known that epigenetic regulatory programs involve DNA methylation, chromatin (histone) modification, and non-coding RNA (small non-coding RNAs or micro-RNAs) in cancer stem cell associated with the EMT [3,21,22].