Hexachlorophene, a disinfectant previously used as a bacteriostatic skin cleanser, has demonstrated WNT/β-catenin pathway inhibition by promoting degradation of β-catenin through the ubiquitin ligase SIAH1 in colon cancer cells and EBV-infected B-lymphoma, as well as inhibition of cell proliferation in colon cancer cells [182,183]. This evidence concerns the gene SIAH1 and malignant colon neoplasm.