The DDR activated as a result of CDT intoxication is the same that is activated following ionizing-radiation DSB [8] leading to an ATM (Ataxia telangiectasia mutated)-dependent cell cycle arrest at G2/M and/or G1/S transition, and initiation of DNA repair (Figure 1) [9,10,11,12], making CDT an inhibitory cyclomodulin [13,14]. This evidence concerns the gene ATM and isolated focal cortical dysplasia type II.