TP53 and colonic neoplasm: To identify the effects of MSM on proliferation, HCT-116 p53 +/+ and HCT-116 p53 −/− colon cancer cells were incubated with different concentrations (100–1000 mM) of MSM for 24 h before performing 3-(4,5-Dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay.