2.3. MSM-Increased Caspase-3 Activity in HCT-116 p53 +/+ and p53 −/− Colon Cancer Cells and Caspase-3 Inhibitor (Z-VAD-fmk) Rescued HCT-116 p53 +/+ and p53 −/− Colon Cancer Cells from MSM-Induced Cell Death. The gene discussed is CASP3; the disease is colonic neoplasm.