In order to analyze the mode of cell death induced by MSM treatment, HCT-116 p53 +/+ and HCT-116 p53 −/− colon cancer cells were incubated with MSM (200, 400, and 600 mM) for 24 h before double-staining with Annexin V-PE/7-AAD. This evidence concerns the gene ANXA5 and colonic neoplasm.