Among these proteins, six are reportedly related to cell survival and death; i.e., RhoGDI, GRP78, TXNDC5, COMD9, EIF4E, and PRDX3, which reportedly affect Rho GTPase activity, ER stress, cancer progression, NF-κB suppression, cell growth, cell cycle progression, and apoptosis [26,27,28,29,30,31]. This evidence concerns the gene HSPA5 and cancer.