The subsequent reported association between TL1A and ankylosing spondylitis 49 and the breeding of the DR‐3−/− mouse genotype on a DBA/1 background, which results in a mouse that spontaneously develops ankylosing enthesopathy 64, led to a recent study of the role of DR‐3 in osteoblast function in vitro and in vivo. This evidence concerns the gene TNFRSF25 and ankylosing spondylitis.