PI and related metabolites are important second messengers involved in mitogen activated protein kinase and protein kinase B (PKB/Akt) signaling pathways.20 Although low levels of PS and PI have been reported in plasma, their significance in circulation are not entirely clear, but may influence the structure and function of lipoproteins.21, 22, 23, 24 No differences were found in lyso-PC and SM among HC, SS and NASH. This evidence concerns the gene WNK2 and metabolic dysfunction-associated steatohepatitis.