PARP1 and breast carcinoma: Currently, trials with PARPi are underway in early stage breast cancer, and are under consideration as a prevention strategy in BRCA1 and BRCA2 mutation carriers and for an array of non-oncologic conditions that stem from its role in inhibition of ADP-ribosylation of other PARP family members including tankyrases, ATP/NAD depletion and transcriptional regulation [18–20].