Depletion of either UAP1 or PGM3 with two independent siRNAs significantly reduced cell viability of both LNCaP and CWR22Rv1 cells in comparison to cells treated with the control siRNA, consistent with expression of both these enzymes being important for prostate cancer cell survival (Fig. 5D, Supplementary Figs. 5 & 6). This evidence concerns the gene PGM3 and Familial prostate cancer.