EDEM3 stimulates mannose trimming of N-glycans from total glycoproteins, and also enhances glycoprotein endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins (Hirao et al., 2006, Olivari and Molinari, 2007) (Fig. 7A), which is particularly important in the context of cancer where increased metabolic needs lead to the accumulation of faulty proteins (Olzmann et al., 2013). This evidence concerns the gene EDEM3 and cancer.