Decreased expression of CSGALNACT1 also increased the numbers of dead and apoptotic cells, and significantly decreased cell viability in both LNCaP and CWR22Rv1 cells in comparison to cells treated with the control siRNA, suggesting a key role for the CSGALNACT1 enzyme in PCa cell biology (Fig. 6E and Supplementary Figs. 5 & 6). Here, CSGALNACT1 is linked to posterior cortical atrophy.