AR and Familial prostate cancer: However, these studies have generally focused either on the use of a single model of prostate cancer (LNCaP or its in vitro derived subclones) (Massie et al., 2007, Wang et al., 2007, Rajan et al., 2011), only on AR regulated genes with nearby AR genomic binding sites (Massie et al., 2011, Sharma et al., 2013), or have been limited by genome coverage on microarrays (Rajan et al., 2011, Massie et al., 2007, Massie et al., 2011, Wang et al., 2009a).