Within our dataset of 700 reciprocally regulated genes were many established classes of AR target genes, including cell cycle regulators (e.g. ORC5L), signalling molecules implicated in PCa (e.g. HER3), and genes with roles in central metabolism and biosynthetic pathways (e.g. CAMKK2), as well as many additional novel androgen-regulated genes (Supplementary Tables 4 & 5). The gene discussed is ORC5; the disease is posterior cortical atrophy.