Taken together, our data suggests that the O-glycosylation and core synthesis enzymes GALNT7, ST6GalNAC1 and GCNT1 are induced by androgens in PCa cells at the protein level, and that production of these enzymes could be important for the synthesis of important cancer-associated O-glycans and contribute to PCa cell viability. Here, GCNT1 is linked to posterior cortical atrophy.