In order to test whether CT2 might also protect from diet-induced or genetically-induced obesity, we kept small molecule treated flies on a high-fat diet (HFD) or treated flies deficient for the brummer lipase (Grönke et al., 2005), the fly homolog of the mammalian adipose triglyceride lipase (ATGL; (Haemmerle et al., 2006)), with CT2. The gene discussed is PNPLA2; the disease is obesity due to melanocortin 4 receptor deficiency.