Despite the high diagnostic sensitivity of >95% for SLE,[7] ANA has a relatively low specificity.[8–10] Nonetheless, as anti-dsDNA, C3, C4, ESR, and ANA are all potentially related to lupus activity, we used these antibodies to correlate with the severity of dry eye in SLE patients. This evidence concerns the gene BTG3 and Keratoconjunctivitis sicca.