Despite the high diagnostic sensitivity of >95% for SLE,[7] ANA has a relatively low specificity.[8–10] Nonetheless, as anti-dsDNA, C3, C4, ESR, and ANA are all potentially related to lupus activity, we used these antibodies to correlate with the severity of dry eye in SLE patients. The gene discussed is C3; the disease is Keratoconjunctivitis sicca.