The AJCC 2010 TNM staging system is prognostic for the survival of p-NETs, which has already been validated in some previous studies.[11–16] However, this system has simultaneously been proven to show some drawbacks which limited its wider clinical use for p-NETs.[13–16] For example, it does not consider histological grade or molecular subtypes such as mitosis and Ki-67 staging, though it recommends that tumor grade should be reported in conjunction with tumor stage. The gene discussed is MKI67; the disease is neoplasm.