It was ascertained that the conversion of progesterone to androstenedione accelerated in theca cells of PCOS ovaries, leading to progesterone scarcity in PCOS women.[27–29] Progesterone deficiency was prone to facilitate LH secretion in PCOS patients, as reported by Fiad et al,[30] resulting in various disturbances. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.