It is also a ligand for intercellular adhesion molecule-1 and is an important mediator of cell–cell interaction and adhesion.[17] In this case of secondary postoperative peritonitis and inflammatory process related to severe hemorrhage, we might hypothesize that needs for fibrinogen to ensure safe wound healing were probably much higher than in isolated nonsevere bleeding, the more so as a recent experimental animal study demonstrated that fibrin polymer formation is vital to S aureus clearance and ultimately host survival in S aureus induced peritonitis.[18]. This evidence concerns the gene ICAM1 and peritonitis.