As presented in Table 2, univariate regression analysis showed that there were a host of factors (including hypertension, higher NYHA classification, statins usage, higher serum levels of creatinine, ALT, NT-proBNP and Hs-CRP, lower serum levels of hemoglobin, HDL cholesterol, and ALB as well as more severe MR) were significantly associated with all-cause mortality in patients with HFrEF complicating CHD (P <0.20). This evidence concerns the gene NPPB and Hypertension.