There were no significant differences in lineage negative (Lin-, Fig 4B), c-Kit+/Lin-/Sca-1- (KLS negative, Fig 4C), c-Kit+/Lin-/Sca-1+ (KLS positive, Fig 4E), multipotent progenitors (MPP, KLS positive/CD34+/Flk-2lo-pos, Fig 4F), megakaryocyte-erythroid progenitors (MEP, KLS negative/CD34-/FcgR3-, Fig 4G), common myeloid progenitors (CMP, KLS negative/CD34-/FcgR3lo, Fig 4H), or granulocyte-monocyte progenitors (GMP, KLS negative/CD34-/FcgR3+, Fig 4I) in AML or MDS mice compared to controls. Here, RPS6KB2 is linked to myelodysplastic syndrome.