MAP1LC3A and neoplasm: In LC1 (S12 Fig) and LC3 (S9 Fig), the tumor patients with evidence of overall shorter cell-free DNA fragments compared to healthy controls, the increase in mutant allele frequency in fractions 20–50 bp shorter than the peak fragment length associated with each library was not as substantial; however, selecting these fractions also did not diminish the mutant allele frequency (Fig 6E).