TP53 and hepatocellular carcinoma: The graph of the symmetric SROC curve showed that the AUC of IHC-determined p53 overexpression was 0.8230 (standard error = 0.0218) with a Q-value of 0.7562 (standard error = 0.0197), indicating that IHC-determined p53 overexpression had an overall moderate level of accuracy in the prediction of p53 mutations in HCC (Fig 4A).