The results of our meta-analysis, which included 1,659 HCC patients from 36 studies, demonstrated that p53 protein overexpression has a moderate diagnostic concordance to mutational assays in the identification of p53 gene mutations in HCC, with a pooled SEN of 0.83 (95% CI: 0.80–0.86) and SPE of 0.74 (95% CI: 0.71–0.76). The gene discussed is TP53; the disease is hepatocellular carcinoma.