TF and cancer: Circulating EVs are reported to play a role in cancer progression, such as carcinogenesis/metastasis and neovascularization/tumor growth, and cancer-associated thrombosis, such as venous thromboembolism (VTE).[8] [9] [10] [11] Tissue factor (TF) is not only the primary cellular initiator of blood coagulation but also a modulator of angiogenesis and metastasis in cancer.