NR1D1 and depressive symptom measurement: The expressions of Hbb-b1 (S4A Fig) and Nr1d1 (S4B Fig) are raised, as well as the expressions of Gad1 (S4C Fig), Mbp (S4D Fig) and Slc6a11 (S4E Fig) are decreased in CUMS-induced depression mice, compared to the control mice (p<0.01).