The decreased expressions of mRNAs in CUMS-induced depression mice include Slc6a11, Hap1, Gad1, Gad2, Gng4, Slc32a1, Doc2g, Slc32a1, Magel2, Prkcd, Ngfr, Dusp1, Th, Itih3, Cacna2d2, Arc, Mbp, Peg10, Fos, and so on. This evidence concerns the gene PRKCD and major depressive disorder.