Based on the bioinformatics of mRNA-guided protein translation (KEGG database), the downregulations of these genes and their translated proteins in Table 1 are associated to the dysfunction of the following signaling pathways and processes in the mPFC neurons from depression-like mice, such as the GABAergic synapses, dopaminergic synapses, synaptic vesicle recycling, amphetamine/morphine addictions, neurotrophin signaling, MAPK signaling and chemokine-cytokine receptor signaling (Table 2). Here, BDNF is linked to major depressive disorder.