The positive enrichment for genes with promoters containing Pax4 motifs could be related to the observations that the paralogue Pax5 interacts with Elk3 [51], and aberrant Pax5-Elk3 fusion proteins are found in childhood precursor B-cell acute lymphoblastic leukaemia [52]. This evidence concerns the gene ELK3 and precursor B-cell acute lymphoblastic leukemia.