There is also negative enrichment for genes up-regulated in MEWO cells (melanoma) after 48h of methionine deprivation, and positive enrichment for genes with promoter regions [-2kb,2kb] around transcription start site containing the motif GGGTGGRR which matches annotation for PAX4: paired box gene 4 and genes up-regulated in NHEK cells (normal epidermal keratinocytes) after UVB irradiation. The gene discussed is PAX4; the disease is melanoma.