Additionally, a number of transcription factors that regulate cell proliferation, differentiation and transformation were down-regulated such as AFF3 (Lymphoid Nuclear Protein4, FC = 2.7), STAT3 (Signal Transducer and Activator of Transcription 3, FC = 2.1), HIVEP1 (Human Immunodeficiency Virus Type I Enhancer Binding Protein 1, FC = 2.3), FOXO1 (Forkhead Box O1, FC = 2.0), and FOSB (FBJ Murine Osteosarcoma Viral Oncogene Homolog B, FC = 2.3) [80–83]. Here, STAT3 is linked to osteosarcoma.