DSG3 and Autoimmunity: This etiology of APS1/APECED B cell autoimmunity is strikingly similar to proposed origins of highly mutated anti-desmoglein-3 antibodies in autoimmune pemphigus (Di Zenzo et al., 2012) and of anti-GM-CSF antibodies pathognomonic in pulmonary alveolar proteinosis (Piccoli et al., 2015).