Quantitative PCR of macrophages accumulating at the tumour site revealed that the downregulation of HMGB1 in B16 cells was associated with a significant induction of the expression of the M1 macrophage marker CD8028, whereas lamin-shRNA-transduced B16 tumours were associated with a significant upregulation of the M2 markers YM1, Fizz1, and IL-10 (Fig. 6b). The gene discussed is IL10; the disease is neoplasm.