From a functional view MeCp2 has been demonstrated to display multiple binding features to several proteins80, e.g. to methyl-cytosine binding domain protein 2 (MBD2)88 or neurological relevant proteins like α-thalassemia/mental retardation, X-linked protein (ATRX)89 and γ-synuclein90, which underlines its potential to modulate molecular pathways in the course of neurodegeneration. Here, MBD2 is linked to Intellectual disability.