Beside nucleus proteins, numerous mitochondrial proteins displayed glaucoma associated level decrement, e.g. ADP/ATP translocase 3 (ANT3), pyruvate dehydrogenase component subunit ß (PDHE1-B) and cytochrome C oxidase subunit 7A2 (COX7A2) (Table 1, Fig. 5). The gene discussed is COX7A2; the disease is glaucoma.