We also note that α-synuclein, which is accumulated in PD patient brain tissue and is degraded in part through the lysosome compartment, did not appear altered in accumulation in Lrrk2 or Rab7l1 deficient kidney in mice at 11–14 months of age (data not shown), consistent with 2 previous studies of Lrrk2 KO mice22, 23. Here, LRRK2 is linked to Parkinson disease.