BTG3 and lymphopenia: Out of the classification criteria for the respective AARDs, we have identified the following clinical findings that could warrant the second-level tests even in the case of low-titre ANA positivity or ANA negativity: Raynaud’s phenomenon, photosensitivity or malar rash, persistent oral or ocular dryness, leucopenia or lymphopenia, significant increase in the creatine phosphokinase (CPK) enzyme, persistent arthritis, thrombotic events, or recurrent miscarriages.