NFE2L2 and colon carcinoma: The observed Nrf2/ARE-activating potency of AOH in the CHO reporter gene assay is in line with earlier reports on the induction of the Nrf2-pathway in HT29 colon carcinoma cells resulting in enhanced levels of Nrf2/ARE-regulated detoxifying enzymes such as GST and γ-GCL (Tiessen et al. 2013a).