HIF1A and neoplasm: Furthermore, quantitation of HIF1-1α expression demonstrated a significant increase in HIF-1α levels in tumors after administration of i.a. CDDP (2.8 ± 0.7 % of remaining viable tumor tissue) compared with tumors exposed to i.a. vehicle (0.6 ± 0.6 %), i.v. CDDP (0.4 ± 0.2 %) or i.v. vehicle (0.3 ± 0.1 %; ANOVA: p < 0.001; Fig. 5c).