Also, dietary supplements such as curcumin showed to increase G0/G1 cell cycle arrest and induce apoptosis through inhibition of DNMT1 and p65; this resulted in decrease in p65 binding to the DNMT1 promoter implying therapeutic potential of curcumin as an adjuvant treatment in acute myelocytic leukemia [53]. This evidence concerns the gene DNMT1 and acute myeloid leukemia.