To examine the effect of liraglutide administration in the specific context of β-amyloid plaque pathology, the aim of the present study was therefore to assess neurobehavioral and molecular effects of long-term liraglutide treatment in two APP/PS1 transgenic mouse models of Alzheimer’s disease carrying different clinical APP/PS1 mutations. Here, PSEN1 is linked to early-onset autosomal dominant Alzheimer disease.