A multivariate analysis was used to identify the most informative molecular features of cyst fluids and to compare them to the commonly used serum biomarkers for ovarian cancer, HE4 (human epididymis protein 4) and CA-125 (Bast et al., 1983; Hellström et al., 2003) (Table 2). The gene discussed is WFDC2; the disease is cyst.