Indeed, chronic treatment of young SCH (from one to six months of age) with a combination of enalapril (angiotensin-converting enzyme inhibitor, ACEI) and losartan (angiotensin receptor blocker, ARB) improves vascular function and retards the development and progression of dilated cardiomyopathy, suggesting that vascular RAS plays a role in the onset of HF [20]. Here, ACE is linked to hydrops fetalis.