ACE mRNA expression was lower in one-month-old SCH than in age-matched CT hamsters (39% ± 9% in SCH vs. 100% in CT; n = 7, p < 0.05), but increased to 141% ± 19% at two months (n = 7, p < 0.05), and to 215% ± 45% at three months (n = 5, p < 0.05), before reaching a plateau of 123% ± 14% at four months. Here, ACE is linked to spindle cell hemangioma.