FLII and acquired epidermolysis bullosa: While Flii over-expressing mice have a normal life expectancy and do not display a blistering phenotype, the effects of Flii on skin architecture were shown to contribute to decreased cell adhesion, irregular hemidesomosome structure, decreased COL7 expression, altered integrin signalling, impaired focal adhesion turnover and increased skin blistering in experimental models of EBA [12,48,69].