The results of immunoblot and IHC suggested that LAMP‐2 was up‐regulated in the AP model and its extent was positively correlated with the incubated level of H2S. Although LAMP‐2 is indispensable, its regulations by AP induction and treatments against incubated level of H2S are not directly associated with the genuine status of autophagosome–lysosome fusion. The gene discussed is LAMP2; the disease is alkaline phosphatase measurement.