These data show that COBL rearrangements are recurrently found in IKZF1 Δ1-8, and are also found in cases with intragenic deletions of IKZF1 (IKZF1-COBL fusions), suggesting a relationship between genes located at 7p12.1 (IKZF1, DDC, GRB10, and COBL) and cancer. This evidence concerns the gene IKZF1 and cancer.