Our data suggest that IKZF1 Δ1-8 promotes the development of a leukemogenic process that is independent of alterations in EBF1 and BTG1. Furthermore, a recent study found that mutual BTG1 and IKZF1 deletions cooperatively increased the incidence of relapse in pediatric BCP-ALL cases. This evidence concerns the gene IKZF1 and acute lymphoblastic leukemia.