As Tspan8 is a CIC marker in PaCa and CoCa and is associated with integrins as well as engaged in TEX biogenesis [9, 48–50], we were particularly interested, whether CD44v6 regulates Tspan8 expression at the transcriptional or the post-transcriptional level. The gene discussed is TSPAN8; the disease is permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.