Notably, flow cytometry of the gated tumor cell population and immunohistochemistry of the matrigel plug showed partial regain of CD44v6 expression and upregulated Tspan8, α6β4 and CXR4 expression in A818.4-CD44v6kd cells of holoclone TEX-treated mice (Figure 8B-8D). Here, TSPAN8 is linked to neoplasm.