We also defined the action of RARAα1, RARα2 and PML-RAR shRNAs on 3 transcription factors controlling APL blast granulocytic maturation, i.e. PU.1 [27, 28], cEBPβ [29, 30] and STAT1α [31] (Figure 3C). This evidence concerns the gene RARA and acute promyelocytic leukemia.